Time is not the same for everyone. How covid-19 changed social acceleration in neoliberal society

This paper is a personal attempt to rethink critically the social impact of the Covid-19 pandemic, trying to discuss about some changes, which came out in that tragic period, in the way of living time and space. There are several ways in which the COVID-19 pandemic has affected these two main structural dimensions of society and the response strategies used by people, groups, and social organizations, depending on the geographical area. There are trends that have had a highly differentiated impact, which have shown that the concept of time is not the same for everyone. Other trends have had a transversal impact, reconfiguring the ideas of present and future. Precariousness and uncertainty, that coincide with an existential specific condition of our contemporary, now take on a new meaning. Before the pandemic, the neoliberal development model seemed to have no alternative. Now, the possibility of an alternative model is imaginable, not only for the critics of it, but also for a large part of public opinion, which now even considers it necessary. The possibility of an alternative becomes concrete and achievable due to the impact that the Covid-19 pandemic has had on the structural dimensions of time and space in social life.

The right times. Reconfigurations of post Covid-19 social work

The spread of the new Sars-CoV-2 coronavirus marked the start of a long phase of health emergency and quickly led to the adoption of an articulated strategy to contain the contagion. Starting from March 2020, this had important effects on the main areas of individual and collective life also in our country. Priorities of intervention and unprecedented challenges have therefore been imposed on organizations and institutions first of all in the health sector but no less in the economic and social sphere. The aim of the article is to outline an updated profile of the rhythms and professional strategies of social work in Tuscany. Taking advantage of some key concepts and giving voice to the operators through some recent research results, the article analyzes the paths of reorganization of the times and working methods of those who work with the most fragile and vulnerable and question the adequacy of spaces for individual planning and sustainability, with a dedicated attention to the intertwining of individual time and social time.

Innovations in COVID times: which lessons to learn for the cultural industry?

The COVID-19 pandemic, and the lockdown of populations and businesses that followed, disrupted the operations of many industries. It also paved the way for a large number of innovations and for an overall technological acceleration, both from companies and from consumers. More than other sectors, culture was largely affected by the crisis through the closing of theatres and of borders and had no other solution than adaptation and innovation in order to survive. This paper discusses a number of such innovations, both in terms of technology and of business models for the cultural industry (i.e. performing arts). Consumers' evaluation of such innovations is assessed through a quantitative survey involving streaming experiences with theatre programs and broadcasted concerts.

Atrial Torsades De Pointes Post Covid Myocarditis

Background: Among patients with COVID-19 infection, the risk of adverse cardiovascular outcome, particularly myocarditis and dysrhythmias remain elevated at least up to one year after infection. We present a case of atrial tachycardia and atrial Torsades de Pointes from COVID myocarditis, persisted 6 months after infection, which was successfully managed by ablation. Objective(s): A 25-year-old female presented with mild COVID-19 infection, Omicron variant, in May 2022. One month after, her Covid infection resolved;she presented with symptomatic atrial tachycardia, paroxysmal atrial fibrillation and flutter. ECG showed multiple blocked premature atrial contractions (PAC) (Figure 1A). Holter monitor showed PAC triggered atrial tachycardia degenerating to paroxysmal atrial fibrillation, atrial Torsades de Pointes. She has mild persistent troponin elevation. Echocardiography was normal. Cardiac MRI showed evidence of mild myocarditis with subepicardial late Gadolinium enhancement (LEG) along the lateral mid-apical left ventricular wall and edema. (Figure 1B). She was treated with Colchicine for 2 months. Repeat cardiac MRI 4 months after COVID infection showed resolution of edema and LGE. However, her symptomatic PAC and atrial tachycardia did not respond to betablocker and amiodarone. She underwent electrophysiology study. Activation mapping of PAC using CARTO revealed earliest activation at the right anterior atrial wall, with close proximity to tricuspid valve;unipolar signal showed QS pattern, bipolar signal showed 16 msec pre-PAC (Figure 1C and 1D). Mechanical pressure from ThermoCool SmartTouch ablation catheter (Biosense Webster Inc.) at this site suppressed the PAC. Radiofrequency ablation resulted with an initial acceleration and then disappearance of the PAC. We did not isolate pulmonary veins or ablate cavotricuspid isthmus. Post ablation, PAC and atrial fibrillation were not inducible on Isoproterenol. Method(s): N/A Results: Covid myocarditis can result in dysrhythmia that lingers long after Covid myocarditis has resolved. Covid myocarditis can be caused by direct viral invasion of myocytes or more commonly is inflammatory related to cytokine release and edema. Our case demonstrates that dysrhythmias can persist despite resolution of myocarditis. Catheter ablation can successfully to treat these arrhythmias. Conclusion(s): This case highlights the importance of recognizing cardiac dysrhythmia as possible the long-term cardiac complications of COVID-19, requiring specific treatment such as catheter ablation. [Formula presented]Copyright © 2023

Characteristics of cardiotocography in pregnant women with mild COVID-19 in the third trimester.

Objective. To study the characteristics of cardiotocography (CTG) and pregnancy outcomes in patients who had a mild coronavirus infection in the third trimester. Patients and methods. The parameters and variations of CTG and pregnancy outcomes were analyzed in 32 low-risk pregnant women who experienced mild COVID-19 in the third trimester (the study group) and in 30 pregnant women (matched pairs) who had no coronavirus infection (the comparison group). Results. A total of 375 CTGs were analyzed: 221 in the study group and 154 in the comparison group. Normal CTG recordings were found in 87% of pregnant women in the study group, which was significantly less frequent than in those without COVID-19 (97%) (p = 0.02), and suspicious CTG in 10 and 1.3%, respectively, which was 3.38-fold more frequent than in the comparison group (p = 0.04). Pathological CTG recordings were observed only in two women in the study group. The features of CTG in women who had a mild form of COVID-19 in the third trimester were a significant decrease in the number of accelerations, short-term variation (STV) in the range of 3 to 5 ms, long-term variation (LTV) <50 ms, a tendency toward tachycardia and low heart rate variability (<5 ms), and prolonged decelerations. The frequency of fetal asphyxia and neonatal morbidity was higher in the study group. Conclusion. COVID-19 even in its mild form may have a negative effect on the fetus, increasing the frequency of fetal hypoxia and neonatal asphyxia.Copyright © 2023, Dynasty Publishing House. All rights reserved.

Mundane emotions: Losing yourself in boredom, time and technology

Marketing and consumer research has drawn attention to the positive and joyful emotional features of consumer tribes. However, research has little to say on boredom, an emotional state already prevalent in consumers' lives, yet exacerbated during the COVID-19 pandemic due to lockdown restrictions that prevented tribal consumption experiences. Informed by Heidegger's understanding of boredom as a fundamental mood tied to temporality, this research uses semi-structured interviews to identify two kinds of boredom – superficial and profound boredom – and their specific temporal dynamics. Superficial boredom is common and refers to a situational restlessness in which people desire distractions. In contrast, profound boredom refers to an existential discomfort in which people struggle with their sense of self, but ultimately can result in the discovery of tribal passions. We explain superficial boredom as a symptom of a dominant temporal regime that comprises connectivity and acceleration. Together these temporal logics fragment and compress time in ways that encourage mundane social media consumption that simply fills time. We also explain how profound boredom stems from an abundance of uninterrupted time spent in relative solitude. In extending Heidegger's theory of boredom to analyse contemporary boredom in an era where digital technology is ubiquitous, our research contributes to consumer research's understanding of mundane emotions and discusses what it means to be bored together.

DISABILITY AND COVID-19 TESTING: A CROSS-SECTIONAL RADx-UP STUDY

Background: Nearly 26% of adults in the U.S. live with disability and are more likely to experience chronic health conditions, barriers to healthcare, and severe COVID-19 illness. Therefore, COVID-19 testing of adults living with disability is important to consider. The purpose of this study was to explore relationships between disability and COVID-19 testing, infection, and related challenges. Method(s): A Rapid Acceleration of Diagnostics-Underserved Population (RADx-UP) project in Miami, FL determined disability with a modified version of the Washington Group General Disability Measure. HIV serostatus and COVID-19 vaccination were confirmed with medical records. COVID-19 testing and infection history were self-reported. Statistical analyses included chi-squared tests and multiple binary logistic regression;variance inflation factors were calculated to ensure absence of collinearity. Result(s): A total of 1,689 RADx-UP participants with an average age of 55+/-12.3, 51% male, 49% Black non-Hispanic, 23% living with HIV (86% virally suppressed), and 76% received at least one dose of a COVID-19 vaccine. Nearly 40% were disabled, 37% reported employment disability, and 21% were functionally disabled (disability that interferes with performance of daily activities). Despite recruitment from the same sources, PLWH, compared to those without HIV, were more likely to be disabled (52% vs 36%;p< 0.0001), report employment disability (63% vs 30%;p< 0.0001), and report functional disability (29% vs 18%;p< 0.0001). Those with employment disability were less likely to have ever been tested for COVID-19 compared to those without (81% vs 85%;p=0.026). Employment disability was also associated with lower odds of having ever tested positive for COVID-19 after adjustment for demographics, health insurance, HIV, COVID-19 vaccination, smoking, and lung disease (aOR, 0.62;95% CI, 0.43-0.90;p=0.013). Disability was associated with greater odds of transportation challenges (aOR, 2.33;95% CI, 1.76-3.08;p< 0.0001), illicit drug use (aOR, 1.92;95% CI, 1.49-2.47;p< 0.0001), and smoking (aOR, 1.74;95% CI, 1.39-2.17;p< 0.0001). Compared to those without, those with transportation challenges (14% vs 40%;p< 0.0001) and illicit drug use (18% vs 30%;p=0.001) were more likely to postpone medical care. Conclusion(s): Lower COVID-19 testing rates may contribute to underestimated COVID-19 positivity rates in adults living with disability. Challenges with transportation and substance abuse contribute to less engagement in care.

Accelerating Tuberculosis Preventive Treatment among Tanzanians Living with Hiv

Background: People living with HIV (PLHIV) bear 20 times higher risk of acquiring tuberculosis (TB) compared to people without HIV. The World Health Organization recommends TB preventive treatment (TPT) for PLHIV to reduce this risk. However, according to the 2020 Global TB Report, only half of PLHIV were started on TPT globally in 2019, with the lowest coverage observed in low-income countries including Tanzania, where TPT provision is part of the standard of care for eligible PLHIV in Tanzania. We describe programmatic efforts to scale up TPT in 11 regions accounting for half of the 1.5 million PLHIV on ART in Tanzania. Method(s): Starting in 2018, PEPFAR, through the U.S. Centers for Disease Control and Prevention (CDC), supported the Government of Tanzania to accelerate TPT provision by: (1) training and mentoring healthcare workers, (2) integrating isoniazid into supply chain plans at the regional level, and (3) convening quarterly meetings at national and regional levels for program and supply chain monitoring and coordination. Additionally, CDC launched focused regional support interventions, with TPT among its priorities, aiming to facilitate real-time data-driven site monitoring, increased accountability, and on-the-ground coordination with local health authorities and implementing partners. We analyzed routine programmatic data reported in PEPFAR's data reporting system for fiscal years (FY) FY2018 through FY2021. Result(s): The number of PLHIV of all ages who initiated TPT increased from 67,510 in FY2018 to 268,909 in FY2019. Despite coinciding with the COVID-19 pandemic, the initiation numbers in FY2020 were sustained at 264,465 and dropped by about one-third in FY2021 (182,823) compared to the previous year. TPT completion rates among those initiated also showed a positive trend;38% in FY2018, 85% in FY2019, 90% in FY2020, and 91% in FY2021. Conclusion(s): Our findings demonstrate substantial acceleration of TPT initiation and a significant increase in TPT completion rates over the four-year period in 11 regions in Tanzania. The policy of once-in-a-lifetime TPT for PLHIV means fewer people are eligible for TPT over time, which might account for lower numbers of PLHIV initiated on TPT in FY2021. Completion remained high among those who initiated TPT. The strategic shift focusing on capacity building, supply chain strengthening, and site-level monitoring may have contributed to the improvements in TPT initiation and completion.

Clinical trials during the pandemic: research design and lessons

The COVID-19 pandemic has required a substantial coordinated international effort to develop effective treatments and vaccines, which has led to an acceleration in innovation in clinical research with the rapid adoption of pragmatic, open, adaptive platform trials for new therapeutics. Large platform trials such as RECOVERY, SOLIDARITY and REMAP-CAP have demonstrated the ability to recruit thousands of patients across multiple sites in a short period of time, resulting in therapies that have now been adopted into clinical practice. Therapies tested for COVID-19 include repurposed antivirals, immunomodulatory drugs, convalescent plasma and, more recently, novel therapeutics developed specifically to target SARS-CoV-2. Challenges have included ethical and practical issues of delivering clinical research during a pandemic, some duplication of effort and the testing of some therapies with a low likelihood of success. COVID-19 has required acceleration of the process of clinical trial conduct, from grant funding to approvals and simplification of trial processes. Many of the innovations and simplifications to clinical trial conduct that have featured so prominently during the COVID-19 pandemic are likely to be just as valuable in a post-pandemic world. An important legacy of the pandemic may be a more efficient and effective way of delivering clinical research in the future.Copyright © ERS 2021.

Accounts receivable management in transport organizations

In a crisis in the international settlement system, there is a need to strengthen payment discipline and accelerate payments. The consequences of the COVID-19 pandemic have also led to a reduction in the liquid means of transport organizations and also increased the problem. Acceleration of repayment of accounts receivable increases cash security. The methods of accounts receivable management integrated into the system based on a client-oriented approach are investigated. The proposed system allows you to track the balances of accounts receivable, comparing them with sales volumes and turnover indicators. The concept of the cycle of accounts receivable circulation is formulated. It is revealed that the existing indicators of turnover of accounts receivable and the volume of sales do not accurately reflect the quality of repayment of accounts receivable, the relationship between these indicators is not revealed. They do not disclose the possibility of additional release of funds from settlements with debtors. To solve this problem, a new indicator has been introduced - the rate of repayment of receivables. An approach is proposed to substantiate the expediency of accelerating payments based on the elasticity of revenue from the sale of transport services to the rate of repayment of receivables. © The Authors, published by EDP Sciences.

How have firms transformed and executed IT-enabled remote work initiatives during the COVID-19 pandemic? Conceptualization and empirical evidence from Spain

This paper examines how firms have transformed and executed IT-enabled remote work initiatives during the COVID-19 pandemic. After examining archival data on a sample of 100 firms in Spain, we discover three types of IT-enabled remote work firm's strategies: leader, agile, and survival. Leader companies have a competitive advantage over agile companies, which in turn have a competitive advantage over survival organizations. We find that firm size was crucial to executing remote work firm's initiatives as a leader or survival. The industry significantly affected the implementation of remote work firm's initiatives during the three pivotal periods in the telecommunications industry. © 2023

Device-Edge-Cloud Collaborative Acceleration Method Towards Occluded Face Recognition in High-Traffic Areas

Wearing masks can effectively inhibit the spread and damage of COVID-19. A device-edge-cloud collaborative recognition architecture is designed in this paper, and our proposed device-edge-cloud collaborative recognition acceleration method can make full use of the geographically widespread computing resources of devices, edge servers, and cloud clusters. First, we establish a hierarchical collaborative occluded face recognition model, including a lightweight occluded face detection module and a feature-enhanced elastic margin face recognition module, to achieve the accurate localization and precise recognition of occluded faces. Second, considering the responsiveness of occluded face detection services, a context-aware acceleration method is devised for collaborative occluded face recognition to minimize the service delay. Experimental results show that compared with state-of-the-art recognition models, the proposed acceleration method leveraging device-edge-cloud collaborations can effectively reduce the recognition delay by 16%while retaining the equivalent recognition accuracy. IEEE

Adapting the GACT-X Aligner to Accelerate Minimap2 in an FPGA Cloud Instance

Featured ApplicationFast long-read assembly to reference in AWS cloud FPGA instances.In genomic analysis, long reads are an emerging type of data processed by assembly algorithms to recover the complete genome sample. They are, on average, one or two orders of magnitude longer than short reads from the previous generation, which provides important advantages in information quality. However, longer sequences bring new challenges to computer processing, undermining the performance of assembly algorithms developed for short reads. This issue is amplified by the exponential growth of genetic data generation and by the slowdown of transistor technology progress, illustrated by Moore's Law. Minimap2 is the current state-of-the-art long-read assembler and takes dozens of CPU hours to assemble a human genome with clinical standard coverage. One of its bottlenecks, the alignment stage, has not been successfully accelerated on FPGAs in the literature. GACT-X is an alignment algorithm developed for FPGA implementation, suitable for any size input sequence. In this work, GACT-X was adapted to work as the aligner of Minimap2, and these are integrated and implemented in an FPGA cloud platform. The measurements for accuracy and speed-up are presented for three different datasets in different combinations of numbers of kernels and threads. The integrated solution's performance limitations due to data transfer are also analyzed and discussed.

Clinical and paraclinical manifestation COVID-19 in different age children

Purpose - to establish the clinical and paraclinical manifestations of the course of COVID-19 in children, depending on age to predict the severity of the disease's manifestation. Materials and methods. The 60 children aged from 3 months to 17 years old with laboratory-confirmed SARS-CoV-2 were examined. All patients underwent general clinical, laboratory, and instrumental examinations and received therapy according to Ukrainian National protocol. SARS-CoV-2 infection was confirmed by real-time PCR. Results. Thus, in young children COVID-19 begins acutely (90.0%) with intoxication (75.0%), fever (65.0%), nasal congestion (25.0%), rhinorrhea (20.0%), dry cough (60.0%), increased ESR and C-reactive protein (55.0%). The course of COVID-19 in children 4-6 years is accompanied by acute onset (85.71%), fever (85.71%), pharyngitis (85.71%), lymphopenia (28.56%), and no CT signs of lesions (71.43%). In children 7-12 years old, COVID-19 causes intoxication (88.89%), fever (83.33%), pharyngitis (55.56%), dry cough (77.78%), lymphocytosis (16.67%) with accelerated ESR (38.89%) and pneumonia (38.89%). The course of COVID-19 in children was older than 13 years old characterized by fever (73.33%), pharyngitis (66.67%), dry cough (73.33%), olfactory loss (20.0%), leukopenia (20.0%), ESR acceleration (20.0%), and a decrease in prothrombin (13.33%) without pulmonary lesions (73.33%). Conclusions. These data suggest that the severity and duration of clinical and laboratory manifestations of COVID-19 depend on the child's age. The course of COVID-19 in children of all age groups is mostly of moderate severity with a favorable prognosis ((56.67%) hospitalized children did not have any complications). Only children from 7 to 12 years old need additional attention due to the severe manifestations of intoxication (88.89%) and the risk of complications with pneumonia (38.89%). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.Copyright © 2022 Modern Pediatrics. Ukraine. All rights reserved.

Students' Perception of Online Learning During the COVID-19 Pandemic: Polish and Ukrainian Perspectives

The COVID-19 pandemic prompted a rapid shift to online learning at universities, leading to an acceleration of changes directed at creating more inclusive education models. The goal of this research is to explore various aspects of online learning patterns, including students' online behavior, and attitude towards online communication. The study incorporates qualitative and qualitative data analysis. Based on 1562 survey responses from Polish and Ukrainian students, it has been found that there are still differences in digital competencies between men and women, which may be rooted in traditional gender roles. The analysis of students' attitudes towards online education also identified both positive and negative aspects of this form of learning, providing insight into areas that could be improved. The main research limitation stems from the interpretative nature of the findings, which have restricted generalization power. The research findings may be useful in shaping future educational policies at Polish and Ukrainian universities. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Research Acceleration in Self-Driving Labs: Technological Roadmap toward Accelerated Materials and Molecular Discovery

The urgency of finding solutions to global energy, sustainability, and healthcare challenges has motivated rethinking of the conventional chemistry and material science workflows. Self-driving labs, emerged through integration of disruptive physical and digital technologies, including robotics, additive manufacturing, reaction miniaturization, and artificial intelligence, have the potential to accelerate the pace of materials and molecular discovery by 10–100X. Using autonomous robotic experimentation workflows, self-driving labs enable access to a larger part of the chemical universe and reduce the time-to-solution through an iterative hypothesis formulation, intelligent experiment selection, and automated testing. By providing a data-centric ion to the accelerated discovery cycle, in this perspective article, the required hardware and software technological infrastructure to unlock the true potential of self-driving labs is discussed. In particular, process intensification as an accelerator mechanism for reaction modules of self-driving labs and digitalization strategies to further accelerate the discovery cycle in chemical and materials sciences are discussed.

Implementation of Digital Marketing in Micro, Small, and Medium Enterprises (MSMEs) in Indonesia During the COVID-19 Pandemic

In Indonesia, micro, small, and medium enterprises (MSMEs) cover nearly 90% of the business entities and become the backbone of national economic growth. However, during the COVID-19 pandemic, they encountered challenges in their marketing, which impacted their sales volume. Jember Regency has the highest number of MSMEs in East Java, Indonesia, and is renowned for agro-industry products such as peanut cookies (Kue Kacang). However, most MSMEs in Jember are lacking in applying digital marketing. It is not in line with the acceleration and development of the technology and information flows in 4.0, which has required MSMEs to adapt to these developments in their business. The purpose of this study was to reveal the implementation of digital marketing and the obstacles encountered in improving their sales performance. This study applied a qualitative approach. The research data was collected through semistructured in-depth interviews, observation, and documentation. The informants involved in this study are business owners of peanut cookie MSMEs in Jember. This study found that they use the owner's private account on Facebook and WhatsApp as their primary digital marketing platforms, while others used Instagram and TikTok. Surprisingly, none of them used e-commerce platforms such as due to their cluelessness with the system. In addition, the shortage of input production during the peak season has been a recurring issue for decades. Further, the result discovered that digital marketing makes it easier for MSMEs owners to communicate with consumers, provide information, and expand the market during the COVID-19 pandemic. © 2023 IEEE.

SARS-CoV-2 Kerala Isolate Spike Protein Induces Cancer Proliferating Markers for Lung and Breast Cancer: An In Silico Approach

Background: Coronavirus disease (COVID 19) has been emerging as a major threat to humans all over the world. Severe Acute Respiratory Syndrome CoronaVirus 2 (nSARS-CoV-2) is the causative agent for the disease resulting in severe acute respiratory illness. Earlier, it took several years to come up with a vaccine or other sorts of treatments for viral diseases. But now with the advent of biotechnology and development of bio-informatic tools, the process has been accelerated. The WHO reports 39,806,488 affected cases and 1,112,208 deaths till today all over the world (17 Oct 2020). nSARS-CoV-2 has a greater influence on people with comorbidities mainly cancer. Objective(s): The study herein attempts to understand the binding affinity of the spike protein of the novel coronavirus with the lung and breast cancer marker proteins by docking and ClusPro analysis. Method(s): The analysis was conducted in reference to hACE2 (human Angiotensin Converting Enzyme 2), the receptor of nSARS-CoV-2. Total 22 different marker proteins were analyzed using ClusPro. Result(s): BRCA1 (Breast Cancer type 1 susceptibility protein) and CXCR4 (a chemokine receptor belong-ing to the G protein coupled receptor family) were found to exhibit higher binding affinities.-73.82 kcal/mol and-66.45 kcal/mol were the global energies they showed upon binding to S protein respective-ly. Conclusion(s): Therefore, novel SARS-CoV-2 has a higher chance of inducing cancer in non-cancerous individuals and aids in cancer acceleration in cancer patients. This poses a threat to cancer patients and immunocompromised individuals. The study can be exploited to identify the optimal drug delivery system for novel SARS CoV2.Copyright © 2022 Bentham Science Publishers.

Post‐pandemic cities: An urban lexicon of accelerations/decelerations

COVID‐19 has stimulated renewed societal and academic debate about the future of cities and urban life. Future visons have veered from the ‘death of the city' to visual renderings and limited experiments with novel 15 minute neighbourhoods. Within this context, we as a diverse group of urban scholars sought to examine the emergent ‘post'‐COVID city through the production of an urban lexicon that investigates its socio‐material contours. The urban lexicon makes three contributions. First, to explore how the pandemic has accelerated certain processes and agendas, while at the same time, other processes, priorities and sites have been decelerated and put on hold. Second, to utilise this framing to examine the impacts of the pandemic on how cities are governed, how urban geographies are managed and lived, and how care emerged as a vital urban resource. Third, to tease out what might be temporary intensifications and what may become configurational in urban governance, platforming, density, technosolutionism, dwelling, crowds, respatialisation, reconcentration, care, improvisation and atmosphere. The urban lexicon proposes a vocabulary for describing and understanding some of the key contours of the emergent post‐pandemic city. [ABSTRACT FROM AUTHOR] Copyright of Transactions of the Institute of British Geographers is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

COVID-19 Vaccines: Fabrication Techniques and Current Status

The year 2020 was the most challenging period due to the havoc caused by the outbreak of novel coronavirus SARS-CoV-2. Scientists and researchers all around the world have endeav-ored every possible approach to find solutions in context to therapeutics and vaccines to control the spread of this life-threatening virus. The acceleration instigated by the outbreak of SARS-CoV-2 and its mutated strains has leveraged the use of numerous platform technologies for the development of vaccines against this unfathomable disease. Vaccines could play an important role in miti-gating the effects of COVID-19 and reducing the ongoing health crisis. Various innovative plat-forms like proteins, nucleic acids, viruses, and viral vectors have been exploited to fabricate vaccines depicting almost 90% of efficacy like BNT162b2, AZD1222, Ad5-nCoV, etc. Some of these vaccines are multipotent and have shown potent activity against newly emerged malicious strains of SARS-CoV-2 like B.1.351 and B.1.1.7. In this review article, we have gathered key findings from various sources of recently popularized vaccine candidates, which will provide an overview of potential vaccine candidates against this virus and will help the researchers to investi-gate possible ways to annihilate this menace and design new moieties.Copyright © 2022 Bentham Science Publishers.